ABSTRACT
Introduction: Aplastic anemia is a potentially life-threateningfailure of hematopoiesis, characterized by pancytopenia andhypocellular bone marrow. Aplastic anemia if untreated resultsin very high mortality. Early diagnosis of Aplastic anemias isessential for appropriate management of the patient.Aims and Objectives: The aim of the study was to assess theprevalence of the condition in southern odisha admitted to thisinstitute and to study the clinico-hematological profile for theassessment of severity by using the modified Camitta criteriaaiding in their management protocol.Materials and Methods: This study was carried outprospectively in the Department of Pathology, MKCGMedical College & Hospital during the period of June 2017 toMay 2019. A detailed clinical history, physical examination,Complete Blood Count, CPS, Reticulocyte count, Bone marrowaspiration and Biopsy were performed in each case and theobservations were evaluated using simple and basic statisticaltools.Results: There are 63 diagnosed cases of aplastic anemiaduring the study period. Out of 63 cases 36 cases are male(57.14 %) and 27 cases are female (42.86 %) indicating a malepreponderance of this disease and male to female ratio is 1.3:1. We also found that, Aplastic anemia has a bi modal agedistribution. Fever, generalized weakness and bleeding due tothrombocytopenia are commonest clinical manifestations. All63 cases are sub categorized into 38 Non severe cases (60.32%), 17 severe cases (26.98 %) and 8 cases are very severe(12.70 %).Conclusion: A good knowledge on clinical and hematologicalparameters will certainly aid in early diagnosis of Aplasticanemia and sub-categorization for treatment. But in adeveloping country financial constraints and lack of awarenessforms a major drawback in patient management. So earlydiagnosis of Aplastic Anemia reduce the treatment cost as wellas will decrease mortality.